Endocrine Abstracts

Pregabalin is a highly used drug for the effective treatment of diabetic neuropathic pain. This study compared the efficacy and safety of a controlled-release (CR) Pregabalin tablet (GLA5PR GLARS-NF1) with an immediate-release (IR) Pregabalin capsuleafter 12 week administration in patients with diabetic peripheral neuropathy. In multicenter, randomized, double- blind, active- controlled, parallel- group, phase III study, the primary outcome was to confirm that CR pregabalin wi...

A 30-year-old lady was transferred to our hospital at 37 weeks of pregnancy. Hypertension was noted at 24 weeks of gestation and managed with methyldopa and labetalol. Despite treatment, BP was labile with a systolic of 90–220 and diastolic of 50–129 mmHg. She reported occasional palpitations but not chest pain or shortness of breath. The patient had a history of migrainous headaches but not hypertension prior to pregnancy. Her brother had previously had an operation...

Decamethylcyclopentasiloxane(D5) is one of the most common chemical ingredient for cosmetic products, cleansing agents, hairdye, dry cleaning solvent and personal hygiene supplies. D5 is also known as estrogenic chemical. It can be absorbed through skin, airosol, and even oraly. People are exposed to D5 in daily environment. However, the risk of prenatal exposure to D5 has not yet been fully understood. Recent research shows that imbalance of dam’s estrogen induces brain ...

Objectives: The aim of this study was to evaluate the diagnostic performance of biopsy criteria in four society ultrasonography (US)-based risk stratification systems (RSSs) or thyroid imaging reporting and data system (TIRADS) including the 2021 Korean (K)-TIRADS for thyroid nodules.Methods: Ovid-Medline, EMBASE, Cochrane, and KoreaMed databases were searched and other eligible articles by manual search were included to identify original articles invest...

Objectives: Radiofrequency ablation (RFA) is considered an alternative treatment for benign thyroid nodules and malignant thyroid cancers. There were various clinical practice guidelines from international societies for ablation of benign thyroid nodules. Recently, RFA is becoming a promising treatment choice for recurrence thyroid cancer, and RFA is suggested as a minimally invasive treatment for low-risk papillary thyroid microcarcinoma (PTMC). Several international societie...

Background: Optimal production of cellular energy and metabolites in mitochondria is one of the most important factors in endocrine organs that accomplish the momentary adaptation to ligand stimulation, such as insulin secretion and aldosterone biosynthesis. Although it has been suggested that thyroid gland function is also largely dependent on mitochondrial function, functional behavior of thyroid gland on compromised mitochondrial function remained to be identified. In this ...

Background: Hemorheologic alterations or changes in blood viscosity have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters in type 2 diabetes patients at different stages of chronic kidney disease (CKD) and assessed their possible role as early markers of diabetic nephropathy and renal insufficiency.Methods: One hundred and five patients with type 2 diabetes were divide...

Recently, dipeptidyl peptidase-IV (DPP-IV) inhibitor, a major anti-hyperglycaemic agent, has received substantial attention as a possible therapeutic target for inflammatory diseases such as atherosclerosis. However, the direct molecular mechanisms through which DPP-IV inhibitor mediates anti-inflammatory effects in vascular endothelial cells have not been clarified. The effects of the DPP-IV inhibitor, gemigliptin, were analysed in human umbilical vein endothelial cells (HUVE...